지연된 의도적 재식술을 통한 치주 조직 재생 방법의 고찰
Delayed intentional replantation: new approach for periodontal regeneration and establishment of theoretical background
김유경, 김동주, 이은웅, 임현창, 이중석, 정의원, 윤정호, 김의성, 이승종, 최성호,
소속 상세정보
김유경 ( Kim You-Kyoung ) - 연세대학교 치과대학 치주과학교실
김동주 ( Kim Dong-Ju ) - 연세대학교 치과대학 치주과학교실
이은웅 ( Lee Eun-Ung ) - 연세대학교 치과대학 치주과학교실
임현창 ( Lim Hyun-Chang ) - 연세대학교 치과대학 치주과학교실
이중석 ( Lee Jung-Seok ) - 연세대학교 치과대학 치주과학교실
정의원 ( Jung Ui-Won ) - 연세대학교 치과대학 치주과학교실
윤정호 ( Yun Jeong-Ho ) - 인하대학교 의과대학 치과학교실
김의성 ( Kim Eui-Seong ) - 연세대학교 치과대학 보존과학교실
이승종 ( Lee Seung-Jong ) - 연세대학교 치과대학 치주과학교실
최성호 ( Choi Seong-Ho ) - 연세대학교 치과대학 치주과학교실
KMID : 0362720150530070485
Abstract
Purpose: Delayed intentional replantation was introduced as a new alternative to treat the teeth with severe periodontal involvement. The purpose of this study was to elucidate the possibility of delayed intentional replantation and establish theoretical backgrounds.
Materials and Methods: Studies were performed into the following two subjects; Clinical evaluation of patients who underwent delayed intentional replantation using clinical and radiographic data. Severe periodontitis involved teeth were carefully extracted and proper time for delayed replantation was evaluated by analyzing inflammation markers (IL-6, TNF- ). Theoretical studies for efficacy of delayed intentional replantation using (-)-Epigallocatechin-3-gallate (EGCG) for preservation of periodontal ligament cells on root surface by minimizing inflammation and treatment of inflammatory extraction sockets.
Results: Meaningful success ratio and survival rate were found in delayed intentional replantation showing reduced bone loss and maintained bone level. Additionally, viability of EGCG applied periodontal ligament cells was much higher than control group. Also, EGCG promoted healing of inflammatory extraction sockets by inhibiting inflammatory cell proliferation.
Conclusion: Within the limitations of this study, 1-2 weeks after extraction is an appropriate time to do delayed intentional
replantation. Also, EGCG provides helpful effects on viability of periodontal ligament cells and periodontium.
키워드
Delayed intentional replantation; Tooth extraction; Periodontitis; (-)-Epigallocatechin-3-gallate (EGCG); Anti-inflammatory effect
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